TRIM11 FISH Probe
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FISH Probe Products & Services
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TRIM11 FISH Probe
The TRIM11 FISH probe is designed to hybridize to the TRIM11 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe
is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes
hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
Turnaround Time: 7-10 Business Days Shipping Time: 1-2 Day Expedited Shipping
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]
Primary intradermal nodular unpigmented tumors in several patients were analyzed for genetic similarities. It was thought that the CRTC1-TRIM11 fusion would be a novel genetic marker for the tumor. FISH analysis was used with our TRIM11 break apart probe to confirm the presence of the gene fusion. Other FISH analysis was done before TRIM11 as "diagnostic molecular testing". Of the five tumors under analysis, each of them did contain the CRTC1-TRIM11 fusion, which was concluded to be specific to the type of nodular tumor being studied.
Recently, a new entity of cutaneous melanocytic tumor morphologically resembling clear cell sarcoma was identified in 5 adult patients, characterized by CRTC1-TRIM11 gene fusion. In this study, 4 new cases of this malignancy were analyzed using IHC, RNA sequencing, and FISH. TRIM11 rearrangement was verified using Empire Genomics’ break-apart TRIM11 FISH probe. Tumors were all positive for SOX10 and MiTF, mostly positive for S100 protein, and only focally expressed other melanocytic biomarkers (Melan-A and HMB45).