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TRB Break Apart FISH Probe

Empire Genomics’ TRB Break Apart FISH Probe is designed to flank the TRB gene and is typically used for detecting TRB rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
TRBBA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
TRBBA-20-AQOR 20 (40 μL) 200 μL
TRBBA-20-GOGR 20 (40 μL) 200 μL
TRBBA-20-GORE 20 (40 μL) 200 μL
TRBBA-20-GRGO 20 (40 μL) 200 μL
TRBBA-20-GRRE 20 (40 μL) 200 μL
TRBBA-20-ORGR 20 (40 μL) 200 μL
TRBBA-20-REGO 20 (40 μL) 200 μL
TRBBA-20-REGR 20 (40 μL) 200 μL

Gene Summary

T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: TRB

Gene Name: T-cell Receptor Beta Locus

Chromosome: CHR7: 142299010-142813286

Locus: 7q34

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: TRB FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: TRB-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping