TPSAB1 FISH Probe
The TPSAB1 FISH probe is designed to hybridize to the TPSAB1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TPSAB1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TPSAB1-20-RE | 20 (40 μL) | 200 μL |  |
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| TPSAB1-20-GO | 20 (40 μL) | 200 μL |  |
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| TPSAB1-20-GR | 20 (40 μL) | 200 μL |  |
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| TPSAB1-20-AQ | 20 (40 μL) | 200 μL |  |
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| TPSAB1-20-DIG | 20 (40 μL) | 200 μL |  |
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| TPSAB1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: TPSAB1
Gene Name: Tryptase Alpha/beta 1
Chromosome: CHR16: 1290677-1292555
Locus: 16p13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: TPSAB1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TPSAB1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping