TPMT FISH Probe
The TPMT FISH probe is designed to hybridize to the TPMT gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TPMT-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TPMT-20-RE | 20 (40 μL) | 200 μL |  |
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| TPMT-20-GO | 20 (40 μL) | 200 μL |  |
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| TPMT-20-GR | 20 (40 μL) | 200 μL |  |
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| TPMT-20-AQ | 20 (40 μL) | 200 μL |  |
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| TPMT-20-DIG | 20 (40 μL) | 200 μL |  |
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| TPMT-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
Gene Details
Gene Symbol: TPMT
Gene Name: Thiopurine S-methyltransferase
Chromosome: CHR6: 18128544-18155374
Locus: 6p22.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: TPMT FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TPMT-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping