TOP3B Break Apart FISH Probe
Empire Genomics’ TOP3B Break Apart FISH Probe is designed to flank the TOP3B gene and is typically used for detecting TOP3B rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
SKU | Test Kits | Buffer | Dye Color | Order Now |
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TOP3BBA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL | ||
TOP3BBA-20-AQOR | 20 (40 μL) | 200 μL | ||
TOP3BBA-20-GOGR | 20 (40 μL) | 200 μL | ||
TOP3BBA-20-GORE | 20 (40 μL) | 200 μL | ||
TOP3BBA-20-GRGO | 20 (40 μL) | 200 μL | ||
TOP3BBA-20-GRRE | 20 (40 μL) | 200 μL | ||
TOP3BBA-20-ORGR | 20 (40 μL) | 200 μL | ||
TOP3BBA-20-REGO | 20 (40 μL) | 200 μL | ||
TOP3BBA-20-REGR | 20 (40 μL) | 200 μL |
Gene Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
Gene Details
Gene Symbol: TOP3B
Gene Name: DNA Topoisomerase III Beta
Chromosome: CHR22: 22311402-22337147
Locus: 22q11.22
FISH Probe Protocols
Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: TOP3B FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TOP3B-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping