TOP3B FISH Probe
The TOP3B FISH probe is designed to hybridize to the TOP3B gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TOP3B-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TOP3B-20-RE | 20 (40 μL) | 200 μL |  |
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| TOP3B-20-GO | 20 (40 μL) | 200 μL |  |
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| TOP3B-20-GR | 20 (40 μL) | 200 μL |  |
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| TOP3B-20-AQ | 20 (40 μL) | 200 μL |  |
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| TOP3B-20-DIG | 20 (40 μL) | 200 μL |  |
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| TOP3B-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
Gene Details
Gene Symbol: TOP3B
Gene Name: DNA Topoisomerase III Beta
Chromosome: CHR22: 22311402-22337147
Locus: 22q11.22
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: TOP3B FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TOP3B-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping