TOP2A FISH Probe
The TOP2A FISH probe is designed to hybridize to the TOP2A gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TOP2A-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| TOP2A-20-RE | 20 (40 μL) | 200 μL |  |
|
| TOP2A-20-GO | 20 (40 μL) | 200 μL |  |
|
| TOP2A-20-GR | 20 (40 μL) | 200 μL |  |
|
| TOP2A-20-AQ | 20 (40 μL) | 200 μL |  |
|
| TOP2A-20-DIG | 20 (40 μL) | 200 μL |  |
|
| TOP2A-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
Gene Details
Gene Symbol: TOP2A
Gene Name: DNA Topoisomerase II Alpha
Chromosome: CHR17: 38544772-38574202
Locus: 17q21.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: TOP2A FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TOP2A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping