TNNT3 FISH Probe
The TNNT3 FISH probe is designed to hybridize to the TNNT3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TNNT3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TNNT3-20-RE | 20 (40 μL) | 200 μL |  |
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| TNNT3-20-GO | 20 (40 μL) | 200 μL |  |
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| TNNT3-20-GR | 20 (40 μL) | 200 μL |  |
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| TNNT3-20-AQ | 20 (40 μL) | 200 μL |  |
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| TNNT3-20-DIG | 20 (40 μL) | 200 μL |  |
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| TNNT3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
Gene Details
Gene Symbol: TNNT3
Gene Name: Troponin T3, Fast Skeletal Type
Chromosome: CHR11: 1940798-1959936
Locus: 11p15.5
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: TNNT3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TNNT3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping