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TNFSF11 FISH Probe

The TNFSF11 FISH probe is designed to hybridize to the TNFSF11 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
TNFSF11-20-OR  (Standard Design) 20 (40 μL) 200 μL
TNFSF11-20-RE 20 (40 μL) 200 μL
TNFSF11-20-GO 20 (40 μL) 200 μL
TNFSF11-20-GR 20 (40 μL) 200 μL
TNFSF11-20-AQ 20 (40 μL) 200 μL
TNFSF11-20-DIG 20 (40 μL) 200 μL
TNFSF11-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: TNFSF11

Gene Name: TNF Superfamily Member 11

Chromosome: CHR13: 43136871-43182149

Locus: 13q14.11

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: TNFSF11 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: TNFSF11-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping