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TLR7 FISH Probe

The TLR7 FISH probe is designed to hybridize to the TLR7 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
TLR7-20-OR  (Standard Design) 20 (40 μL) 200 μL
TLR7-20-RE 20 (40 μL) 200 μL
TLR7-20-GO 20 (40 μL) 200 μL
TLR7-20-GR 20 (40 μL) 200 μL
TLR7-20-AQ 20 (40 μL) 200 μL
TLR7-20-DIG 20 (40 μL) 200 μL
TLR7-20-BIO 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: TLR7

Gene Name: Toll Like Receptor 7

Chromosome: CHRX: 12885201-12908480

Locus: Xp22.2

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Mosaicism of XX and XXY cells accounts for high copy number of Toll like Receptor 7 and 8 genes in peripheral blood of men with Rheumatoid Arthritis

In BXSB murine lupus, extra copies of the X-linked TLR7 gene have been shown to aggravate autoimmunity in male mice. This team investigated the trend in human males with rheumatoid arthritis (RA). Our TLR7, Control X and Control Y probes were used to detect TLR7 copy number, and Chromosome X and Y aneuploidy, respectively. About a third of patients were found to have significantly higher copy numbers of TLR7, as well as substantial cellular mosaicism of female (46,XX) and/or Klinefelter (47,XXY) cells among male (46,XY) cells.
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Product Details

Product: TLR7 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: TLR7-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping