TIAM1 FISH Probe
The TIAM1 FISH probe is designed to hybridize to the TIAM1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TIAM1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TIAM1-20-RE | 20 (40 μL) | 200 μL |  |
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| TIAM1-20-GO | 20 (40 μL) | 200 μL |  |
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| TIAM1-20-GR | 20 (40 μL) | 200 μL |  |
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| TIAM1-20-AQ | 20 (40 μL) | 200 μL |  |
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| TIAM1-20-DIG | 20 (40 μL) | 200 μL |  |
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| TIAM1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]
Gene Details
Gene Symbol: TIAM1
Gene Name: T-cell Lymphoma Invasion And Metastasis 1
Chromosome: CHR21: 32490735-32931290
Locus: 21q22.11
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: TIAM1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TIAM1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping