TBC1D4 Break Apart FISH Probe
Empire Genomics’ TBC1D4 Break Apart FISH Probe is designed to flank the TBC1D4 gene and is typically used for detecting TBC1D4 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TBC1D4BA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| TBC1D4BA-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| TBC1D4BA-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| TBC1D4BA-20-GORE | 20 (40 μL) | 200 μL |
|
|
| TBC1D4BA-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| TBC1D4BA-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| TBC1D4BA-20-ORGR | 20 (40 μL) | 200 μL |
|
|
| TBC1D4BA-20-REGO | 20 (40 μL) | 200 μL |
|
|
| TBC1D4BA-20-REGR | 20 (40 μL) | 200 μL |
|
Gene Summary
This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Gene Details
Gene Symbol: TBC1D4
Gene Name: TBC1 Domain Family Member 4
Chromosome: CHR13: 75858808-76056250
Locus: 13q22.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: TBC1D4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TBC1D4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping