SYNE4 Break Apart FISH Probe
Empire Genomics’ SYNE4 Break Apart FISH Probe is designed to flank the SYNE4 gene and is typically used for detecting SYNE4 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SYNE4BA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| SYNE4BA-20-AQOR | 20 (40 μL) | 200 μL |
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| SYNE4BA-20-GOGR | 20 (40 μL) | 200 μL |
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| SYNE4BA-20-GORE | 20 (40 μL) | 200 μL |
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| SYNE4BA-20-GRGO | 20 (40 μL) | 200 μL |
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| SYNE4BA-20-GRRE | 20 (40 μL) | 200 μL |
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| SYNE4BA-20-ORGR | 20 (40 μL) | 200 μL |
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| SYNE4BA-20-REGO | 20 (40 μL) | 200 μL |
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| SYNE4BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene is a member of the nesprin family of genes, that encode KASH (Klarsicht, Anc-1, Syne Homology) domain-containing proteins. In addition to the KASH domain, this protein also contains a coiled-coil and leucine zipper region, a spectrin repeat, and a kinesin-1 binding region. This protein localizes to the outer nuclear membrane, and is part of the linker of nucleoskeleton and cytoskeleton (LINC) complex in the nuclear envelope. LINC complexes are formed by SUN (Sad1, UNC-84)-KASH pairs, and are thought to mechanically couple nuclear components to the cytoskeleton. Mutations in this gene have been associated with progressive high-frequency hearing loss. The absence of this protein in mice also caused hearing loss, and changes in hair cell morphology in the ears. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Gene Details
Gene Symbol: SYNE4
Gene Name: Spectrin Repeat Containing Nuclear Envelope Family Member 4
Chromosome: CHR19: 36008792-36003298
Locus: 19q13.12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: SYNE4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: SYNE4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping