SREBF1 FISH Probe
The SREBF1 FISH probe is designed to hybridize to the SREBF1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SREBF1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| SREBF1-20-RE | 20 (40 μL) | 200 μL |  |
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| SREBF1-20-GO | 20 (40 μL) | 200 μL |  |
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| SREBF1-20-GR | 20 (40 μL) | 200 μL |  |
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| SREBF1-20-AQ | 20 (40 μL) | 200 μL |  |
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| SREBF1-20-DIG | 20 (40 μL) | 200 μL |  |
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| SREBF1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]
Gene Details
Gene Symbol: SREBF1
Gene Name: Sterol Regulatory Element Binding Transcription Factor 1
Chromosome: CHR17: 17714662-17740325
Locus: 17p11.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: SREBF1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: SREBF1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping