SMC1A FISH Probe
The SMC1A FISH probe is designed to hybridize to the SMC1A gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SMC1A-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| SMC1A-20-RE | 20 (40 μL) | 200 μL |  |
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| SMC1A-20-GO | 20 (40 μL) | 200 μL |  |
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| SMC1A-20-GR | 20 (40 μL) | 200 μL |  |
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| SMC1A-20-AQ | 20 (40 μL) | 200 μL |  |
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| SMC1A-20-DIG | 20 (40 μL) | 200 μL |  |
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| SMC1A-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Gene Details
Gene Symbol: SMC1A
Gene Name: Structural Maintenance Of Chromosomes 1A
Chromosome: CHRX: 53401069-53449618
Locus: Xp11.22
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: SMC1A FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: SMC1A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping