SMAD2 FISH Probe
The SMAD2 FISH probe is designed to hybridize to the SMAD2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SMAD2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| SMAD2-20-RE | 20 (40 μL) | 200 μL |  |
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| SMAD2-20-GO | 20 (40 μL) | 200 μL |  |
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| SMAD2-20-GR | 20 (40 μL) | 200 μL |  |
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| SMAD2-20-AQ | 20 (40 μL) | 200 μL |  |
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| SMAD2-20-DIG | 20 (40 μL) | 200 μL |  |
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| SMAD2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Gene Details
Gene Symbol: SMAD2
Gene Name: SMAD Family Member 2
Chromosome: CHR18: 45359465-45457515
Locus: 18q21.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: SMAD2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: SMAD2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping