SMAD1 FISH Probe
The SMAD1 FISH probe is designed to hybridize to the SMAD1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SMAD1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| SMAD1-20-RE | 20 (40 μL) | 200 μL |  |
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| SMAD1-20-GO | 20 (40 μL) | 200 μL |  |
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| SMAD1-20-GR | 20 (40 μL) | 200 μL |  |
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| SMAD1-20-AQ | 20 (40 μL) | 200 μL |  |
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| SMAD1-20-DIG | 20 (40 μL) | 200 μL |  |
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| SMAD1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: SMAD1
Gene Name: SMAD Family Member 1
Chromosome: CHR4: 146402950-146480325
Locus: 4q31.21
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: SMAD1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: SMAD1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping