SKP2 FISH Probe
The SKP2 FISH probe is designed to hybridize to the SKP2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SKP2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| SKP2-20-RE | 20 (40 μL) | 200 μL |  |
|
| SKP2-20-GO | 20 (40 μL) | 200 μL |  |
|
| SKP2-20-GR | 20 (40 μL) | 200 μL |  |
|
| SKP2-20-AQ | 20 (40 μL) | 200 μL |  |
|
| SKP2-20-DIG | 20 (40 μL) | 200 μL |  |
|
| SKP2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]
Gene Details
Gene Symbol: SKP2
Gene Name: S-phase Kinase Associated Protein 2
Chromosome: CHR5: 36152144-36184142
Locus: 5p13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: SKP2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: SKP2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping