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SIRPB1 Break Apart FISH Probe

Empire Genomics’ SIRPB1 Break Apart FISH Probe is designed to flank the SIRPB1 gene and is typically used for detecting SIRPB1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
SIRPB1BA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
SIRPB1BA-20-AQOR 20 (40 μL) 200 μL
SIRPB1BA-20-GOGR 20 (40 μL) 200 μL
SIRPB1BA-20-GORE 20 (40 μL) 200 μL
SIRPB1BA-20-GRGO 20 (40 μL) 200 μL
SIRPB1BA-20-GRRE 20 (40 μL) 200 μL
SIRPB1BA-20-ORGR 20 (40 μL) 200 μL
SIRPB1BA-20-REGO 20 (40 μL) 200 μL
SIRPB1BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Gene Details

Gene Symbol: SIRPB1

Gene Name: Signal Regulatory Protein Beta 1

Chromosome: CHR20: 1545028-1600689

Locus: 20p13

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

SIRPB1 promotes prostate cancer cell proliferation via Akt activation

Although SIRPB1 amplification has been shown to correlate with increased aggressiveness in prostate cancer, the gene’s role in tumor development is still unclear. This study analyzed SIRPB1 amplification in 20 prostate adenocarcinomas using our SIRPB1 probe. The team also used several public prostate cancer data sets to compare SIRBP1 CNVs to clinical outcome in 5170 available samples. Results suggest that the gene plays an important growth-stimulatory role in prostate cancer progression.
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Product Details

Product: SIRPB1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: SIRPB1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping