SHH Break Apart FISH Probe
Empire Genomics’ SHH Break Apart FISH Probe is designed to flank the SHH gene and is typically used for detecting SHH rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SHHBA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| SHHBA-20-AQOR | 20 (40 μL) | 200 μL |
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| SHHBA-20-GOGR | 20 (40 μL) | 200 μL |
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| SHHBA-20-GORE | 20 (40 μL) | 200 μL |
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| SHHBA-20-GRGO | 20 (40 μL) | 200 μL |
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| SHHBA-20-GRRE | 20 (40 μL) | 200 μL |
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| SHHBA-20-ORGR | 20 (40 μL) | 200 μL |
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| SHHBA-20-REGO | 20 (40 μL) | 200 μL |
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| SHHBA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: SHH
Gene Name: Sonic Hedgehog
Chromosome: CHR7: 155595557-155604967
Locus: 7q36.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: SHH FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: SHH-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping