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SEPT5 Break Apart FISH Probe

Empire Genomics’ SEPT5 Break Apart FISH Probe is designed to flank the SEPT5 gene and is typically used for detecting SEPT5 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
SEPT5BA-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
SEPT5BA-20-AQOR 20 (40 μL) 200 μL
SEPT5BA-20-GOGR 20 (40 μL) 200 μL
SEPT5BA-20-GORE 20 (40 μL) 200 μL
SEPT5BA-20-GRGO 20 (40 μL) 200 μL
SEPT5BA-20-GROR 20 (40 μL) 200 μL
SEPT5BA-20-GRRE 20 (40 μL) 200 μL
SEPT5BA-20-REGO 20 (40 μL) 200 μL
SEPT5BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010]

Gene Details

Gene Symbol: SEPT5

Gene Name: Septin 5

Chromosome: CHR22: 19701986-19710845

Locus: 22q11.21

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Acute myeloid leukemia with KMT2A-SEPT5 translocation: A case report and review of the literature

Acute myeloid leukemia (AML) is commonly characterized by a chromosomal rearrangement of KMT2A. Up to 94 translocation partner genes have been identified thus far. This case study focuses on a rare gene translocation of KMT2A with SEPT5. FISH analysis was performed with two probes including our SEPT5 probe. FISH confirmed rearrangement of the KMT2A and SEPT5 genes. The study concluded that they had a new case of AML KMT2A-SEPT5 fusion, making it one of nine reported cases.
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Product Details

Product: SEPT5 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: SEPT5-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping