SENP6 Break Apart FISH Probe
Empire Genomics’ SENP6 Break Apart FISH Probe is designed to flank the SENP6 gene and is typically used for detecting SENP6 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SENP6BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SENP6BA-20-AQOR | 20 (40 μL) | 200 μL |
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| SENP6BA-20-GOGR | 20 (40 μL) | 200 μL |
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| SENP6BA-20-GORE | 20 (40 μL) | 200 μL |
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| SENP6BA-20-GRGO | 20 (40 μL) | 200 μL |
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| SENP6BA-20-GROR | 20 (40 μL) | 200 μL |
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| SENP6BA-20-GRRE | 20 (40 μL) | 200 μL |
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| SENP6BA-20-REGO | 20 (40 μL) | 200 μL |
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| SENP6BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
Gene Details
Gene Symbol: SENP6
Gene Name: SUMO1/sentrin Specific Peptidase 6
Chromosome: CHR6: 76311621-76427994
Locus: 6q14.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: SENP6 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: SENP6-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping