SCUBE3 FISH Probe
The SCUBE3 FISH probe is designed to hybridize to the SCUBE3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SCUBE3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| SCUBE3-20-RE | 20 (40 μL) | 200 μL |  |
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| SCUBE3-20-GO | 20 (40 μL) | 200 μL |  |
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| SCUBE3-20-GR | 20 (40 μL) | 200 μL |  |
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| SCUBE3-20-AQ | 20 (40 μL) | 200 μL |  |
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| SCUBE3-20-DIG | 20 (40 μL) | 200 μL |  |
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| SCUBE3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the signal peptide, complement subcomponents C1r/C1s, Uegf, bone morphogenetic protein-1 and epidermal growth factor-like domain containing protein family. Overexpression of this gene in human embryonic kidney cells results in secretion of a glycosylated form of the protein that forms oligomers and tethers to the cell surface. This gene is upregulated in lung cancer tumor tissue compared to healthy tissue and is associated with loss of the epithelial marker E-cadherin and with increased expression of vimentin, a mesenchymal marker. In addition, the protein encoded by this gene is a transforming growth factor beta receptor ligand, and when secreted by cancer cells, it can be cleaved in vitro to release the N-terminal epidermal growth factor-like repeat domain and the C-terminal complement subcomponents C1r/C1s domain. Both the full length protein and C-terminal fragment can bind to the transforming growth factor beta type II receptor to promote the epithelial-mesenchymal transition and tumor angiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Details
Gene Symbol: SCUBE3
Gene Name: Signal Peptide, CUB Domain And EGF Like Domain Containing 3
Chromosome: CHR6: 35182189-35218609
Locus: 6p21.31
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: SCUBE3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: SCUBE3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping