SACS Break Apart FISH Probe
Empire Genomics’ SACS Break Apart FISH Probe is designed to flank the SACS gene and is typically used for detecting SACS rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SACSBA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| SACSBA-20-AQOR | 20 (40 μL) | 200 μL |
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| SACSBA-20-GOGR | 20 (40 μL) | 200 μL |
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| SACSBA-20-GORE | 20 (40 μL) | 200 μL |
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| SACSBA-20-GRGO | 20 (40 μL) | 200 μL |
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| SACSBA-20-GRRE | 20 (40 μL) | 200 μL |
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| SACSBA-20-ORGR | 20 (40 μL) | 200 μL |
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| SACSBA-20-REGO | 20 (40 μL) | 200 μL |
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| SACSBA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. The authors of a publication on the effects of siRNA-mediated sacsin knockdown concluded that sacsin protects against mutant ataxin-1 and suggest that "the large multi-domain sacsin protein is able to recruit Hsp70 chaperone action and has the potential to regulate the effects of other ataxia proteins" (Parfitt et al., PubMed: 19208651). A pseudogene associated with this gene is located on chromosome 11. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Details
Gene Symbol: SACS
Gene Name: Sacsin Molecular Chaperone
Chromosome: CHR13: 23902964-24007841
Locus: 13q12.12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: SACS FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: SACS-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping