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RREB1 FISH Probe

The RREB1 FISH probe is designed to hybridize to the RREB1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

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Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
RREB1-20-OR  (Standard Design) 20 (40 μL) 200 μL
RREB1-20-RE 20 (40 μL) 200 μL
RREB1-20-GO 20 (40 μL) 200 μL
RREB1-20-GR 20 (40 μL) 200 μL
RREB1-20-AQ 20 (40 μL) 200 μL
RREB1-20-DIG 20 (40 μL) 200 μL
RREB1-20-BIO 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Gene Details

Gene Symbol: RREB1

Gene Name: Ras Responsive Element Binding Protein 1

Chromosome: CHR6: 7107829-7252213

Locus: 6p24.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Comparison of melanoma gene expression score with histopathology, fluorescence in situ hybridization, and SNP array for the classification of melanocytic neoplasms

Melanomas with ambiguous histology can be difficult to distinguish from benign nevi. Cytogenetic tests, therefore, have proven highly useful in differentiating melanomas from benign tumors. This study tested the efficacy of FISH at genetically characterizing 70 morphologically ambiguous melanocytic tumors. Our RREB1 probe was used to identify 6p25 amplifications in the samples. Compared to a gene expression test called myPath, FISH agreed better with histopathologic interpretations, had greater sensitivity, and correlated better with molecular diagnostics.
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Product Details

Product: RREB1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: RREB1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping