RPA2 Break Apart FISH Probe
Empire Genomics’ RPA2 Break Apart FISH Probe is designed to flank the RPA2 gene and is typically used for detecting RPA2 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPA2BA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPA2BA-20-AQOR | 20 (40 μL) | 200 μL |
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| RPA2BA-20-GOGR | 20 (40 μL) | 200 μL |
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| RPA2BA-20-GORE | 20 (40 μL) | 200 μL |
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| RPA2BA-20-GRGO | 20 (40 μL) | 200 μL |
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| RPA2BA-20-GRRE | 20 (40 μL) | 200 μL |
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| RPA2BA-20-ORGR | 20 (40 μL) | 200 μL |
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| RPA2BA-20-REGO | 20 (40 μL) | 200 μL |
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| RPA2BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017]
Gene Details
Gene Symbol: RPA2
Gene Name: Replication Protein A2
Chromosome: CHR1: 28218048-28241236
Locus: 1p35.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: RPA2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: RPA2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping