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RPA2 FISH Probe

The RPA2 FISH probe is designed to hybridize to the RPA2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

SKU Test Kits Buffer Dye Color Order Now
RPA2-20-OR  (Standard Design) 20 (40 μL) 200 μL
RPA2-20-RE 20 (40 μL) 200 μL
RPA2-20-GO 20 (40 μL) 200 μL
RPA2-20-GR 20 (40 μL) 200 μL
RPA2-20-AQ 20 (40 μL) 200 μL
RPA2-20-DIG 20 (40 μL) 200 μL
RPA2-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017]

Gene Details

Gene Symbol: RPA2

Gene Name: Replication Protein A2

Chromosome: CHR1: 28218048-28241236

Locus: 1p35.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Scientific Citations

There are currently no FISH related citations for this gene.

Product Details

Product: RPA2 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: RPA2-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping