RPA1 FISH Probe
The RPA1 FISH probe is designed to hybridize to the RPA1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RPA1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| RPA1-20-RE | 20 (40 μL) | 200 μL |  |
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| RPA1-20-GO | 20 (40 μL) | 200 μL |  |
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| RPA1-20-GR | 20 (40 μL) | 200 μL |  |
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| RPA1-20-AQ | 20 (40 μL) | 200 μL |  |
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| RPA1-20-DIG | 20 (40 μL) | 200 μL |  |
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| RPA1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The nucleoprotein complex protects the single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. This subunit contains four oligonucleotide/oligosaccharide-binding (OB) domains, though the majority of ssDNA binding occurs in two of these domains. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which ssDNA binding domains are utilized. The different binding modes differ in the length of DNA bound and in the proteins with which it interacts, thereby playing a role in regulating different genomic maintenance pathways. [provided by RefSeq, Sep 2017]
Gene Details
Gene Symbol: RPA1
Gene Name: Replication Protein A1
Chromosome: CHR17: 1733272-1802848
Locus: 17p13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: RPA1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: RPA1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping