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RICTOR Break Apart FISH Probe

Empire Genomics’ RICTOR Break Apart FISH Probe is designed to flank the RICTOR gene and is typically used for detecting RICTOR rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
RICTORBA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
RICTORBA-20-AQOR 20 (40 μL) 200 μL
RICTORBA-20-GOGR 20 (40 μL) 200 μL
RICTORBA-20-GORE 20 (40 μL) 200 μL
RICTORBA-20-GRGO 20 (40 μL) 200 μL
RICTORBA-20-GRRE 20 (40 μL) 200 μL
RICTORBA-20-ORGR 20 (40 μL) 200 μL
RICTORBA-20-REGO 20 (40 μL) 200 μL
RICTORBA-20-REGR 20 (40 μL) 200 μL

Gene Summary

RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]

Gene Details

Gene Symbol: RICTOR

Gene Name: RPTOR Independent Companion Of MTOR Complex 2

Chromosome: CHR5: 38938021-39074501

Locus: 5p13.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Correlation between immunohistochemistry and RICTOR FISH amplification in small cell lung carcinoma

Small cell lung carcinoma (SCLC) accounts for approximately 15% of all lung cancers and remains a challenging disease to treat, with no significant improvements in the development of targeted therapies. RICTOR is one of the most frequently amplified genes and a potential therapeutic target in SCLC. This study used IHC and Empire Genomics' RICTOR FISH probe to evaluate RICTOR overexpression and gene amplification in 100 SCLC tumors.
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Correlation between RICTOR overexpression and amplification in advanced solid tumors

RICTOR amplification is common across many solid tumors, and recent studies point to the gene as a potential targetable alteration. This study used IHC to measure RICTOR protein expression and our RICTOR FISH probe to detect RICTOR amplification in 213 advanced solid tumors. RICTOR was found overexpressed in 47% of tumors, and IHC and FISH results were closely correlated, indicating that RICTOR overexpression is associated with tumor progression.
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Product Details

Product: RICTOR FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: RICTOR-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping