RASGRP4 FISH Probe
The RASGRP4 FISH probe is designed to hybridize to the RASGRP4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RASGRP4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| RASGRP4-20-RE | 20 (40 μL) | 200 μL |  |
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| RASGRP4-20-GO | 20 (40 μL) | 200 μL |  |
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| RASGRP4-20-GR | 20 (40 μL) | 200 μL |  |
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| RASGRP4-20-AQ | 20 (40 μL) | 200 μL |  |
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| RASGRP4-20-DIG | 20 (40 μL) | 200 μL |  |
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| RASGRP4-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Gene Details
Gene Symbol: RASGRP4
Gene Name: RAS Guanyl Releasing Protein 4
Chromosome: CHR19: 38899697-38916945
Locus: 19q13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: RASGRP4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: RASGRP4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping