RAN FISH Probe
The RAN FISH probe is designed to hybridize to the RAN gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RAN-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| RAN-20-RE | 20 (40 μL) | 200 μL |  |
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| RAN-20-GO | 20 (40 μL) | 200 μL |  |
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| RAN-20-GR | 20 (40 μL) | 200 μL |  |
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| RAN-20-AQ | 20 (40 μL) | 200 μL |  |
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| RAN-20-DIG | 20 (40 μL) | 200 μL |  |
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| RAN-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: RAN
Gene Name: RAN, Member RAS Oncogene Family
Chromosome: CHR12: 131356616-131360826
Locus: 12q24.33
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: RAN FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: RAN-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping