RAG2 FISH Probe
The RAG2 FISH probe is designed to hybridize to the RAG2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RAG2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| RAG2-20-RE | 20 (40 μL) | 200 μL |  |
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| RAG2-20-GO | 20 (40 μL) | 200 μL |  |
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| RAG2-20-GR | 20 (40 μL) | 200 μL |  |
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| RAG2-20-AQ | 20 (40 μL) | 200 μL |  |
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| RAG2-20-DIG | 20 (40 μL) | 200 μL |  |
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| RAG2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: RAG2
Gene Name: Recombination Activating 2
Chromosome: CHR11: 36613492-36619829
Locus: 11p12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: RAG2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: RAG2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping