RAD17 Break Apart FISH Probe
Empire Genomics’ RAD17 Break Apart FISH Probe is designed to flank the RAD17 gene and is typically used for detecting RAD17 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RAD17BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RAD17BA-20-AQOR | 20 (40 μL) | 200 μL |
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| RAD17BA-20-GOGR | 20 (40 μL) | 200 μL |
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| RAD17BA-20-GORE | 20 (40 μL) | 200 μL |
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| RAD17BA-20-GRGO | 20 (40 μL) | 200 μL |
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| RAD17BA-20-GROR | 20 (40 μL) | 200 μL |
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| RAD17BA-20-GRRE | 20 (40 μL) | 200 μL |
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| RAD17BA-20-REGO | 20 (40 μL) | 200 μL |
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| RAD17BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]
Gene Details
Gene Symbol: RAD17
Gene Name: RAD17 Checkpoint Clamp Loader Component
Chromosome: CHR5: 68665123-68710630
Locus: 5q13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: RAD17 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: RAD17-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping