RAD17 FISH Probe
The RAD17 FISH probe is designed to hybridize to the RAD17 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RAD17-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| RAD17-20-RE | 20 (40 μL) | 200 μL |  |
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| RAD17-20-GO | 20 (40 μL) | 200 μL |  |
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| RAD17-20-GR | 20 (40 μL) | 200 μL |  |
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| RAD17-20-AQ | 20 (40 μL) | 200 μL |  |
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| RAD17-20-DIG | 20 (40 μL) | 200 μL |  |
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| RAD17-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]
Gene Details
Gene Symbol: RAD17
Gene Name: RAD17 Checkpoint Clamp Loader Component
Chromosome: CHR5: 68665123-68710630
Locus: 5q13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: RAD17 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: RAD17-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping