PYGL Break Apart FISH Probe
Empire Genomics’ PYGL Break Apart FISH Probe is designed to flank the PYGL gene and is typically used for detecting PYGL rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PYGLBA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PYGLBA-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PYGLBA-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PYGLBA-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PYGLBA-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PYGLBA-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PYGLBA-20-ORGR | 20 (40 μL) | 200 μL |
|
|
| PYGLBA-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PYGLBA-20-REGR | 20 (40 μL) | 200 μL |
|
Gene Summary
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011]
Gene Details
Gene Symbol: PYGL
Gene Name: Glycogen Phosphorylase L
Chromosome: CHR14: 51371934-51411248
Locus: 14q22.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: PYGL FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PYGL-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping