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PYGL FISH Probe

The PYGL FISH probe is designed to hybridize to the PYGL gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PYGL-20-OR  (Standard Design) 20 (40 μL) 200 μL
PYGL-20-RE 20 (40 μL) 200 μL
PYGL-20-GO 20 (40 μL) 200 μL
PYGL-20-GR 20 (40 μL) 200 μL
PYGL-20-AQ 20 (40 μL) 200 μL
PYGL-20-DIG 20 (40 μL) 200 μL
PYGL-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011]

Gene Details

Gene Symbol: PYGL

Gene Name: Glycogen Phosphorylase L

Chromosome: CHR14: 51371934-51411248

Locus: 14q22.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: PYGL FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: PYGL-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping