PTTG1 Break Apart FISH Probe
Empire Genomics’ PTTG1 Break Apart FISH Probe is designed to flank the PTTG1 gene and is typically used for detecting PTTG1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTTG1BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTTG1BA-20-AQOR | 20 (40 μL) | 200 μL |
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| PTTG1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| PTTG1BA-20-GORE | 20 (40 μL) | 200 μL |
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| PTTG1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| PTTG1BA-20-GROR | 20 (40 μL) | 200 μL |
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| PTTG1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| PTTG1BA-20-REGO | 20 (40 μL) | 200 μL |
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| PTTG1BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Details
Gene Symbol: PTTG1
Gene Name: Pituitary Tumor-transforming 1
Chromosome: CHR5: 159848864-159855746
Locus: 5q33.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PTTG1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PTTG1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping