PTPN12 Break Apart FISH Probe
Empire Genomics’ PTPN12 Break Apart FISH Probe is designed to flank the PTPN12 gene and is typically used for detecting PTPN12 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
SKU | Test Kits | Buffer | Dye Color | Order Now |
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PTPN12BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL | ||
PTPN12BA-20-AQOR | 20 (40 μL) | 200 μL | ||
PTPN12BA-20-GOGR | 20 (40 μL) | 200 μL | ||
PTPN12BA-20-GORE | 20 (40 μL) | 200 μL | ||
PTPN12BA-20-GRGO | 20 (40 μL) | 200 μL | ||
PTPN12BA-20-GROR | 20 (40 μL) | 200 μL | ||
PTPN12BA-20-GRRE | 20 (40 μL) | 200 μL | ||
PTPN12BA-20-REGO | 20 (40 μL) | 200 μL | ||
PTPN12BA-20-REGR | 20 (40 μL) | 200 μL |
Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Gene Details
Gene Symbol: PTPN12
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 12
Chromosome: CHR7: 77166772-77269388
Locus: 7q11.23
FISH Probe Protocols
Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PTPN12 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PTPN12-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping