PTPN1 Break Apart FISH Probe
Empire Genomics’ PTPN1 Break Apart FISH Probe is designed to flank the PTPN1 gene and is typically used for detecting PTPN1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PTPN1BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PTPN1BA-20-AQOR | 20 (40 μL) | 200 μL |
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| PTPN1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| PTPN1BA-20-GORE | 20 (40 μL) | 200 μL |
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| PTPN1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| PTPN1BA-20-GROR | 20 (40 μL) | 200 μL |
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| PTPN1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| PTPN1BA-20-REGO | 20 (40 μL) | 200 μL |
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| PTPN1BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Gene Details
Gene Symbol: PTPN1
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 1
Chromosome: CHR20: 49126890-49201086
Locus: 20q13.13
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PTPN1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PTPN1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping