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PTCH1 FISH Probe

The PTCH1 FISH probe is designed to hybridize to the PTCH1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

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Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
PTCH1-20-OR  (Standard Design) 20 (40 μL) 200 μL
PTCH1-20-RE 20 (40 μL) 200 μL
PTCH1-20-GO 20 (40 μL) 200 μL
PTCH1-20-GR 20 (40 μL) 200 μL
PTCH1-20-AQ 20 (40 μL) 200 μL
PTCH1-20-DIG 20 (40 μL) 200 μL
PTCH1-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. [provided by RefSeq, Aug 2017]

Gene Details

Gene Symbol: PTCH1

Gene Name: Patched 1

Chromosome: CHR9: 98205263-98279247

Locus: 9q22.32

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth

This study investigated various components of the tumor microenvironment (TME) in medulloblastoma, one being astrocytic differentiation. Our PTCH1/Con9 probe was used to detect PTCH1 deletion in 6 cases of SHH-activated medulloblastoma, helping to confirm that astrocytes within the tumor masses shared a common lineage with tumor cells harboring the same genetic lesion.
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Product Details

Product: PTCH1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: PTCH1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping