PSMC1 FISH Probe
The PSMC1 FISH probe is designed to hybridize to the PSMC1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PSMC1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PSMC1-20-RE | 20 (40 μL) | 200 μL |  |
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| PSMC1-20-GO | 20 (40 μL) | 200 μL |  |
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| PSMC1-20-GR | 20 (40 μL) | 200 μL |  |
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| PSMC1-20-AQ | 20 (40 μL) | 200 μL |  |
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| PSMC1-20-DIG | 20 (40 μL) | 200 μL |  |
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| PSMC1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: PSMC1
Gene Name: Proteasome 26S Subunit, ATPase 1
Chromosome: CHR14: 90722893-90738966
Locus: 14q32.11
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PSMC1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PSMC1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping