PSEN1 Break Apart FISH Probe
Empire Genomics’ PSEN1 Break Apart FISH Probe is designed to flank the PSEN1 gene and is typically used for detecting PSEN1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PSEN1BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PSEN1BA-20-AQOR | 20 (40 μL) | 200 μL |
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| PSEN1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| PSEN1BA-20-GORE | 20 (40 μL) | 200 μL |
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| PSEN1BA-20-GRGO | 20 (40 μL) | 200 μL |
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| PSEN1BA-20-GROR | 20 (40 μL) | 200 μL |
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| PSEN1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| PSEN1BA-20-REGO | 20 (40 μL) | 200 μL |
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| PSEN1BA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
Gene Details
Gene Symbol: PSEN1
Gene Name: Presenilin 1
Chromosome: CHR14: 73603142-73690399
Locus: 14q24.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PSEN1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PSEN1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping