PRUNE2 FISH Probe
The PRUNE2 FISH probe is designed to hybridize to the PRUNE2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PRUNE2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PRUNE2-20-RE | 20 (40 μL) | 200 μL |  |
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| PRUNE2-20-GO | 20 (40 μL) | 200 μL |  |
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| PRUNE2-20-GR | 20 (40 μL) | 200 μL |  |
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| PRUNE2-20-AQ | 20 (40 μL) | 200 μL |  |
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| PRUNE2-20-DIG | 20 (40 μL) | 200 μL |  |
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| PRUNE2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Gene Details
Gene Symbol: PRUNE2
Gene Name: Prune Homolog 2
Chromosome: CHR9: 79226291-79521003
Locus: 9q21.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PRUNE2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PRUNE2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping