PRKG1 FISH Probe
The PRKG1 FISH probe is designed to hybridize to the PRKG1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PRKG1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PRKG1-20-RE | 20 (40 μL) | 200 μL |  |
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| PRKG1-20-GO | 20 (40 μL) | 200 μL |  |
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| PRKG1-20-GR | 20 (40 μL) | 200 μL |  |
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| PRKG1-20-AQ | 20 (40 μL) | 200 μL |  |
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| PRKG1-20-DIG | 20 (40 μL) | 200 μL |  |
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| PRKG1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
Gene Details
Gene Symbol: PRKG1
Gene Name: Protein Kinase, CGMP-dependent, Type I
Chromosome: CHR10: 52750910-54058110
Locus: 10q11.23-q21.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PRKG1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PRKG1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping