PRKAR1A Break Apart FISH Probe
Empire Genomics’ PRKAR1A Break Apart FISH Probe is designed to flank the PRKAR1A gene and is typically used for detecting PRKAR1A rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PRKAR1ABA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PRKAR1ABA-20-AQOR | 20 (40 μL) | 200 μL |
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| PRKAR1ABA-20-GOGR | 20 (40 μL) | 200 μL |
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| PRKAR1ABA-20-GORE | 20 (40 μL) | 200 μL |
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| PRKAR1ABA-20-GRGO | 20 (40 μL) | 200 μL |
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| PRKAR1ABA-20-GROR | 20 (40 μL) | 200 μL |
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| PRKAR1ABA-20-GRRE | 20 (40 μL) | 200 μL |
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| PRKAR1ABA-20-REGO | 20 (40 μL) | 200 μL |
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| PRKAR1ABA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]
Gene Details
Gene Symbol: PRKAR1A
Gene Name: Protein Kinase CAMP-dependent Type I Regulatory Subunit Alpha
Chromosome: CHR17: 66508109-66528910
Locus: 17q24.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PRKAR1A FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PRKAR1A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping