PRKAR1A FISH Probe
The PRKAR1A FISH probe is designed to hybridize to the PRKAR1A gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PRKAR1A-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PRKAR1A-20-RE | 20 (40 μL) | 200 μL |  |
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| PRKAR1A-20-GO | 20 (40 μL) | 200 μL |  |
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| PRKAR1A-20-GR | 20 (40 μL) | 200 μL |  |
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| PRKAR1A-20-AQ | 20 (40 μL) | 200 μL |  |
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| PRKAR1A-20-DIG | 20 (40 μL) | 200 μL |  |
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| PRKAR1A-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]
Gene Details
Gene Symbol: PRKAR1A
Gene Name: Protein Kinase CAMP-dependent Type I Regulatory Subunit Alpha
Chromosome: CHR17: 66508109-66528910
Locus: 17q24.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PRKAR1A FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PRKAR1A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping