PRKACA FISH Probe
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PRKACA FISH Probe
The PRKACA FISH probe is designed to hybridize to the PRKACA gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe
is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes
hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
Turnaround Time: 7-10 Business Days Shipping Time: 1-2 Day Expedited Shipping
This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]
Gene Symbol: PRKACA
Gene Name: Protein Kinase CAMP-activated Catalytic Subunit Alpha
A new DNAJB1-PRKACA fusion was recently discovered in fibrolamellar hepatocellular carcinoma (FHCC). This study sought to determine the specificity of this fusion for the disease through molecular and genetic analysis of six PRKACA-rearranged pancreatobiliary neoplasms. Empire Genomics’ PRKACA break apart FISH probe was used to detect PRKACA rearrangements in the tumors. Five cases were found to have DNAJB1-PRKACA fusions and one had ATP1B1-PRKACA fusion.