PRCP FISH Probe
The PRCP FISH probe is designed to hybridize to the PRCP gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PRCP-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PRCP-20-RE | 20 (40 μL) | 200 μL |  |
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| PRCP-20-GO | 20 (40 μL) | 200 μL |  |
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| PRCP-20-GR | 20 (40 μL) | 200 μL |  |
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| PRCP-20-AQ | 20 (40 μL) | 200 μL |  |
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| PRCP-20-DIG | 20 (40 μL) | 200 μL |  |
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| PRCP-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Details
Gene Symbol: PRCP
Gene Name: Prolylcarboxypeptidase
Chromosome: CHR11: 82535408-82611557
Locus: 11q14.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PRCP FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PRCP-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping