PPP2R2B FISH Probe
The PPP2R2B FISH probe is designed to hybridize to the PPP2R2B gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PPP2R2B-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PPP2R2B-20-RE | 20 (40 μL) | 200 μL |  |
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| PPP2R2B-20-GO | 20 (40 μL) | 200 μL |  |
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| PPP2R2B-20-GR | 20 (40 μL) | 200 μL |  |
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| PPP2R2B-20-AQ | 20 (40 μL) | 200 μL |  |
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| PPP2R2B-20-DIG | 20 (40 μL) | 200 μL |  |
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| PPP2R2B-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 55-78 copies in cases of SCA12. [provided by RefSeq, Jul 2016]
Gene Details
Gene Symbol: PPP2R2B
Gene Name: Protein Phosphatase 2 Regulatory Subunit Bbeta
Chromosome: CHR5: 145969067-146461033
Locus: 5q32
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PPP2R2B FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PPP2R2B-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping