PPM1L FISH Probe
The PPM1L FISH probe is designed to hybridize to the PPM1L gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PPM1L-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PPM1L-20-RE | 20 (40 μL) | 200 μL |  |
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| PPM1L-20-GO | 20 (40 μL) | 200 μL |  |
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| PPM1L-20-GR | 20 (40 μL) | 200 μL |  |
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| PPM1L-20-AQ | 20 (40 μL) | 200 μL |  |
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| PPM1L-20-DIG | 20 (40 μL) | 200 μL |  |
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| PPM1L-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Gene Details
Gene Symbol: PPM1L
Gene Name: Protein Phosphatase, Mg2+/Mn2+ Dependent 1L
Chromosome: CHR3: 160473995-160788817
Locus: 3q25.33-q26.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PPM1L FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PPM1L-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping